Everything you need to know about Evista

Everything you need to know about Evista – instructions for use, availability, price and where to buy Raloxifene Evista. Search from mobile devices is possible.

Farmgroups: Estrogens, gestagens; their homologues and antagonists

Active substance: Raloxifene

Instructions for use:

  • Composition and form of release: 1 coated tablet contains raloxifene hydrochloride 60 mg; in a blister pack 14, 28 or 84 pcs.
  • Pharmachologic effect: Pharmacological action – inhibiting bone resorption. Selective estrogen receptor modulator. As an agonist, it affects non-reproductive tissues and as an antagonist, on reproductive ones. Increases the concentration of globulins that bind hormones (sex, thyroxine, corticosteroids) with a simultaneous increase in their total content in the blood without increasing the level of free fraction.
  • Pharmacokinetics: Rapidly absorbed after oral administration by approximately 60%. Before entering the systemic circulation, it undergoes intensive formation of glucuronides. Absolute availability is only 2%. The time to reach the mean maximum plasma concentration and bioavailability depend on interconversions in the systemic circulation and transformations of raloxifene and its glucuronide metabolites in the intestine and liver. In patients with hepatic insufficiency, plasma concentrations are approximately 2.5 times higher than in healthy subjects and correlate with the concentration of bilirubin. It has a large volume of distribution (does not depend on the dose). T1 / 2 in plasma is 27.7 hours. Most of the drug and its metabolites are excreted within 5 days and are found mainly in feces (less than 6% is excreted in the urine).
  • Pharmacodynamics: Normalizes the processes of bone resorption in the postmenopausal period (increases bone mass), reduces calcium loss through the urinary system. Reduces total cholesterol, cholesterol in the LDL fraction, serum fibrinogen, Lp (a) and increases the concentration of HDL-C2 subfraction. Does not stimulate the proliferation of the endometrium, breast tissue, reduces the risk of developing breast cancer.
  • Indications: Prevention of osteoporosis in postmenopausal women.
  • Contraindications: Hypersensitivity, thromboembolism (including history), pulmonary embolism and retinal vein thrombosis, deep vein thrombosis, liver failure, osteoporosis in men, childbearing age (in women).
  • Use during pregnancy and lactation: Not recommended.
  • Side effects: Venous thrombosis, thromboembolism, hot flashes, painful spasms of the calf muscles, peripheral edema.
  • Interaction: With simultaneous administration with warfarin or other coumarin derivatives, prothrombin time may decrease. Cholestyramine reduces absorption.
  • Dosage and administration: Inside, 1 tab. (60 mg) per day (at any time of the day, regardless of food intake). The course of treatment is long. Women can combine with calcium supplements.
  • Storage conditions: List B.: In a dry, dark place, at a temperature not exceeding 30 ° C. Do not freeze or expose to excessive heat or sunlight.
  • Best before date: 2 years
  • Main release forms tablets: 60 mg, 14 tab. 60 mg, 28 tab. 60 mg, 84 tab.
  • Diagnosis: M81.0 – Postmenopausal osteoporosis
  • Directions: Gynecology Hirudotherapy Orthopedics Rheumatology Radiology Traumatology Surgery

Dough for waffles

Waffles are characterized by cellularity, brittleness, porous structure, due to the recipe, dough preparation technology and baking process. The main thing for waffles is to properly prepare the dough, which has its own characteristics. Waffle dough is an emulsion, fat droplets which are dispersed in the mass of dough. Like the pancake dough, it has a fluid consistency. It is rather difficult to prepare such dough manually, and therefore it is better to use a mixer.

When baking, the waffle dough lags well behind the forms, it is preferable to use only the yolks and, if possible, not too much sugar, otherwise the waffles will be overly tinted. Instead of sugar, it is better to use powdered sugar. At the end of the dough preparation, proteins are injected into the resistant foam. As you know, this technique is quite common in the manufacture of various confectionery products, when you need to get whipped, air-saturated dough.

Bake waffles in special waffle irons at 180 ° C for 2 minutes. Before starting baking, grease the waffle iron with vegetable oil. In subsequent baking, the waffle iron can not be lubricated, since there is enough fat in the dough itself.

From the wafer sheets, using a variety of fillings, you can cook cakes, pastries, wafer rolls.

It is only necessary to remember that you can roll the tubes only from hot, pliable wafer sheets. For this purpose, it is better to use round wooden blocks, with the help of which you can very quickly screw the wafer sheet, giving it the desired shape.

We can recommend several different recipes for waffles. As for fillings for them, it is important that they contain as little moisture as possible in order to preserve the brittleness of the waffles.

Massage scrub

The second stage of my technique – scrub massage – deeply and thoroughly cleanses the pores. I never feel that my skin is completely cleansed until I get a scrub massage. At this stage, the skin is deeply cleansed, dry dead cells are removed, the skin becomes silky.

When applying the scrub, repeat the exercises and massage again. To give the scrub more spreadability and to facilitate the sliding of the fingers during the massage, I advise you to wet your fingers. Now you can wash. Rinse your face with warm, then hot water – the kind that your skin will be able to perceive (do not burn yourself, please).

Rinse the face several times until the skin is completely clean. Warm water perfectly enhances the movement of blood in the skin tissues and stimulates the sebaceous glands.

Toweling

It is important to understand well the meaning of the towel wipe procedure. At the end of the cleansing massage, repeat the gymnastics for the face, using a hard white terry towel (if you use the product you need to wash off, wet your face and then wipe dry). Start the massage by wiping at one end of the towel, using it instead of fingers. When you finish wiping the first part of the face, change the area of ​​the towel and go to the next part. For example, if you perform the “Eternal“ O ”exercise, start with the right eye, and with a towel, make a full circle around the eye. Then clean the end of the towel – around the left. Rubbing every part of the face — nose, forehead, area around the mouth, etc. — go to clean areas of the towel. One towel is enough for a long time (do not forget that you can use both sides). During this procedure, not only is blood circulation activated, but you will also see how dirty your face is. If the white towel remains clean, you will know that the skin is clean and you can go to the second stage – the massage scrub. If the skin is still dirty and this and the days on the towel, reapply the cleanser and dry off with a towel or rinse your face and dry it.

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Raloxifene Evista

Raloxifene

IMPORTANT WARNING:

Taking raloxifene may increase the risk that you will develop a blood clot in your legs or lungs. Tell your doctor if you have or have ever had a blood clot in your legs, lungs, or eyes. Your doctor will probably tell you not to take raloxifene. Stop taking raloxifene and call your doctor immediately if you experience any of the following symptoms: leg pain; feeling of warmth in the lower leg; swelling of the hands, feet, ankles, or lower legs; sudden chest pain; shortness of breath; coughing up blood; or sudden changes in vision, such as loss of vision or blurred vision.

Remaining still for a long time may increase the chance that you will develop a blood clot. Your doctor will probably tell you to stop taking raloxifene at least three days before a scheduled surgery and not to take the medication if you require an extended period of bed rest for any reason. If you will be having surgery, be sure to tell your doctor that you are taking raloxifene. If you travel while you are taking raloxifene, avoid remaining still (such as sitting in an airplane or car) for long periods of time during your trip.

If you have coronary artery disease (hardening of the arteries that lead to the heart that may cause chest pain or heart attacks) or if you are at high risk of developing coronary artery disease, taking raloxifene may increase the chance that you will have a serious or fatal stroke. Tell your doctor if you have ever had a stroke or mini-stroke, if you smoke, and if you have or have ever had high blood pressure or an irregular heartbeat.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with raloxifene and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs ) or the manufacturer’s website to obtain the Medication Guide.

Why is this medication prescribed?

Raloxifene is used to prevent and treat osteoporosis (condition in which the bones become thin and weak and break easily) in women who have undergone menopause (change of life; end of menstrual periods). Raloxifene is also used to decrease the risk of developing invasive breast cancer (breast cancer that has spread outside of the milk ducts or lobules into the surrounding breast tissue) in women who are at high risk of developing this type of cancer or who have osteoporosis. Raloxifene cannot be used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women who have already had the condition. Raloxifene also cannot be used to decrease the risk of developing non-invasive breast cancer. Raloxifene is in a class of medications called selective estrogen receptor modulators (SERMs). Raloxifene prevents and treats osteoporosis by mimicking the effects of estrogen (a female hormone produced by the body) to increase the density (thickness) of bone. Raloxifene decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue. This may stop the development of tumors that need estrogen to grow.

How should this medicine be used?

Raloxifene comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take raloxifene at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take raloxifene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take raloxifene even if you feel well. Do not stop taking raloxifene without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking raloxifene,

What special dietary instructions should I follow?

You should eat and drink plenty of foods and drinks that are rich in calcium and vitamin D while you are taking raloxifene. Your doctor will tell you which foods and drinks are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods or if you have a condition that makes it difficult for your body to absorb the nutrients that you eat, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Raloxifene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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Before taking raloxifene. Vorlage:Infobox Chemikalie/Summenformelsuche vorhanden. Product details for Evista; Name: Evista: Agency product number: EMEA/H/C/000184: Active substance: raloxifene hydrochloride. Acheter amoxil. Find patient medical information for Evista oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Learn about the prescription medication Evista (Raloxifene), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized . Tamoxifen and Fareston are other SERMs. Brand name: Raloxifene. Class: SERM (selective estrogen receptor modulator) hormonal therapy. 1. . Drug information on Evista (raloxifene (oral)), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. 2004 Dec 1;96(23):1751-61. . Lilly’s innovative products focus on meeting medical needs in the fields of oncology, cardiovascular, diabetes, critical care, neuroscience, men’s health and . . Raloxifen (Handelsname Evista ®; Hersteller Eli Lilly and Company) ist ein Arzneistoff aus der Gruppe der . Chemical name: Evista. . Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to . Trade Name: Evista ® Drug Type: Raloxifene is a hormone therapy. Easy to read patient leaflet for Evista. International non-proprietary name (INN . . Includes indications, proper use, special instructions, precautions, and possible side effects. NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. Raloxifene is classified as an Selective Estrogen Receptor Modulator (SERM). . 1 1 BNL 3123 AMP 2 Medication Guide 3 EVISTA ® (E-VISS-tah) 4 (raloxifene hydrochloride) 5 Tablets for Oral Use 6 Read the Medication Guide that comes with EVISTA . . . Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. . This page contains answers to some common questions about Evista. General Information. . . J Natl Cancer Inst

 

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